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Registry changes about the Windows System.If this Item is beeing found, it does not necessarily mean an infection.Some Malware like CWS and Smitfraud variants change these settings.It is also possible that these settings have been changed by an administrator (if you have one) or by a legitimate software.Windows System Registry changes include Displaysettingmenus and Controlpanel.
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These Settings can normally not be reversed via the normal Windows User Interface.Some settings pose security risks and some are just annoyances.Also, some settings are redundant, meaning that they can be changed at various positions in the registry thus changing one value may not be enough.
You can either allow Spybot to fix the detection or set it to be ignored.