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Do I need anything else? If not, what can be deleted from my computer that I've downloaded during the course of this fix (for which I most sincerely thank you:crowned: !)

My bad, caught out by the wrong green box, the one I clicked was a registry cleaner, now downloading AVG.

All processes killed
========== OTL ==========
Registry value HKEY_LOCAL_MACHINE\Software\Microsoft\Internet Explorer\Toolbar\\{0494D0D9-F8E0-41ad-92A3-14154ECE70AC} deleted successfully.
Registry...

I'm aware of XP support having ended, I was getting MS popups daily telling me that. As for Windows 7, theoretically it can run it, however I'd need to transfer all my music onto a portable hard...

Forgot to add, yes I did manage to remove MS Security Essentials.

OTL Extras logfile created on: 19/04/2014 17:17:00 - Run 1
OTL by OldTimer - Version 3.2.69.0 Folder = C:\Documents and Settings\SARAH BROUGH\Desktop
Windows XP Home Edition Service Pack 3...

Malwarebytes Anti-Malware log

Malwarebytes Anti-Malware
www.malwarebytes.org

Scan Date: 19/04/2014
Scan Time: 16:49:33
Logfile: mam.txt
Administrator: Yes

# AdwCleaner v3.024 - Report created 19/04/2014 at 01:41:59
# Updated 18/04/2014 by Xplode
# Operating System : Microsoft Windows XP Service Pack 3 (32 bits)
# Username : SARAH BROUGH -...

Panic over, managed to restart process.

The uninstall of MS security essentials has frozen (couldn't do it in safe mode), can you advise how to proceed?

Disabled but made no difference, desktop icons apart from recycle are all rectangular and the task bar was frozen.

Continued...

Alexa: Interface (INavWnd) (Registry key, nothing done)
HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Interface\{8C953EC4-8CFA-44FB-B32E-1249E5505091}

Alexa: Interface (IAlxWebBrowser2)...

Unfortunately the continuation of my first post was deleted, I had to split it into two parts as there was a lot of text to post.

Spybot results

Smitfraud-C.gp: [SBI $EE2EF3B5] User settings...

I have no clue what I'm doing here, all I know is that between shutting the computer down early morning Thursday to firing it back up Thursday night something has happened to make it stop working...