zakka:

It appears that you may have overcome the installation problem with Spybot 1.5.2.20 that you indicated you were having in the following thread:

Perhaps you would like to share in that thread how you were able to overcome the problem so that others who may experience a similar can benefit from your experience.

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I regard to your current problem:

It sounds like Panda Internet Security 2008 is blocking any attempts to modify the HOSTS file regardless if those modifications are in an attempt to block malware sites. That is really a problem that should be taken up and resolved with Panda.

If the previous attempt to modify the HOSTS file is still causing a problem, try the following:
  • Go into Spybot > Immunize.
  • Right click on the right hand pane and select "Deselect all".
  • Scroll down to the bottom of the right hand pane and under Windows check "Global (Hosts)".
  • Click the "Undo" button at the top of the right pane.

If the only problem is when you use Spybot's Immunize facility, eliminate Spybot's immunization of the HOSTS file as follows:
  • Go into Spybot > Immunize.
  • Scroll down to the bottom of the right hand pane until you see that category "Windows" and the item under it "Global (Hosts)".
  • Uncheck "Global (Hosts)" so that no attempts are made to add HOSTS file entries while immunizing.