Spybot-S&D 2 will inform about possible reasons for these problems from a dialog, the help file and forum links, see this screenshot.
On Vista, you need to run the immunization elevated, otherwise all global immunizations will fail. To elevate, right-click the Spybot-S&D shortcut and choose Run as Administrator. See this screenshot.
Microsoft: How to use User Account Control (UAC) in Windows Vista
Spybot - Search & Destroy 2 will offer you to run the Immunization elevated if you do not run it as described above. If you have chosen to not have this dialog shown again when it was previously shown, you can re-enable it by using the Dialogs tab of the Settings window. See this screenshot.
Computer Associates software users
Computer Associates Yahoo! Anti-Spy blocks a few immunization entries in category Internet Explorer (32/64 bit). One of the unimmunized domains would be koolynoody.net currently. CA AntiVirus 8.4.0 might block a larger amount of entries.
More information about this can be found in threads tagged immunization vs. ca.
AVG Antivirus users
AVG Antivirus blocks immunization of about 30 to 120 entries in the Internet Explorer category.
More information about this can be found in threads tagged immunization vs. avg.
ZoneAlarm blocks all immunization of the area Windows: Global (Hosts) by protecting this file against changes. To overcome this protection, you could temporarily lift the lock from ZoneAlarms Firewall > Advanced tab. Don't forget to relock it after immunization.
More information about this can be found in threads tagged immunization vs. za.
STOPzilla blocks all immunization of the area Windows: Global (Hosts) by protecting this file against changes. To overcome this protection, you could temporarily lift the lock. To do so:
- Open Stopzilla
- Click "Real-time Protection"
- Click "Active Enforcers"
- Click "Network"
- Click "Hosts File" to uncheck it
- Click "Apply"
- Click "OK"
Do not forget to reverse this procedure after you've completed immunization. Thanks go to forum user michaelbmcgee for this instructions.
More information about this can be found in threads tagged immunization vs. stopz.
Firefox 2 users
Firefox profiles can be both for Firefox 2 and Firefox 3 at the same time, and just based on the profile folder, it might be a but difficult to guess which one the user is using. Spybot-S&D 1.6.0 therefore tried to be future-compatible and assumed that a profile would be for Firefox 3 if it has not been clearly identified.
There is a trick though how you can enforce it to be identified as a Firefox 2 profile. Go to C:\Documents and Users\Username\Application Data\Mozilla\Firefox\Profiles\something.default, which is your profile folder (path might be slightly different depending on the OS).
- If there is no file named hostperm.1 but one named permissions.sqlite with a filesize of 0 bytes, rename tho later to have the former name.
- If both files exist, delete the permissions.sqlite.
- If only pemissions.sqlite exists and is larger than 0 bytes, delete it and create an empty file named hostperm.1 .
More information about this can be found in threads tagged immunization vs. ff2.
Spybot-S&D 1.6.1 and 2.0 will recognize Firefox 2 vs. Firefox 3 using other criteria which should be less error-prone.