help pleze- how2install from usb when windows vista won't load

[DJ247]

I hae a toshiba satellite M3050-S4829 infected probably from vista 2012 malware and now windows won't boot
system restore won't restore to earlier dates either
I have downloaded combofix onto a USB
put it into the infected computer drive and the light flashes on the drive but at startup the computer just goes into the normal bad routine, start in safe mode, endless cycle, can't restore
how do I get the laptop to read from the USB to use combofix or anything else to restore windows vista?
help help help help
I also had tried to load superantispyware from USB but nothing is showing up
really need to get this working, hope someone can help
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Edit
DJ247,

Please DO NOT RUN ComboFix without being asked Please wait for a volunteer analyst to advise.

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