You can run Avast and Spybot, there both two different programs, Avast is Anti Virus ( and you should never run more than one AV program ) and Spybot is Anti Spyware ( you can have more than one but not to many)
This is what I would do for your other computers, run a cleaner on them and also Malwarebytes and see if there is any improvement, if not feel free to post in the forum . If Malwarebytes picks up a lot of bad entries than I would definitely post so we can see whats going on, but start a new topic, one computer at a time or it can get pretty confusing.
You can up the security setting in IE and give it a try, you can always revert it back if your unhappy with it
Here is a good cleaner, we basically ran it when we ran the OTL fix, this is the stand alone by the same author
ESET Online Scanner I'd like us to scan your machine with ESET OnlineScan
*Note It is recommended to disable onboard antivirus program and antispyware programs while performing scans so there are no conflicts and it will speed up scan time.
Please don't go surfing while your resident protection is disabled!
Once the scan is finished remember to re-enable your antivirus along with your antispyware programs.
Hold down Control and click on the following link to open ESET OnlineScan in a new window. ESET OnlineScan
Click the button.
For alternate browsers only: (Microsoft Internet Explorer users can skip these steps)
Click on to download the ESET Smart Installer. Save it to your desktop.
Double click on the icon on your desktop.
Click the button.
Accept any security warnings from your browser.
Make sure that the option "Remove found threats" is Unchecked
Push the Start button.
ESET will then download updates for itself, install itself, and begin
scanning your computer. Please be patient as this can take some time.
When the scan completes, push
Push , and save the file to your desktop using a unique name, such as
ESETScan. Include the contents of this report in your next reply.
Push the button.
Please make sure you include the following items in your next post:
The log that was produced after running ESET Online Scanner.
This may be a false positive but its not needed so lets delete it
C:\Documents and Settings\WandaS\My Documents\Downloads\registrybooster.exe
These type of programs that clean the registry are really not needed, sometimes they can do more harm than good, remove the wrong entries or entry and it can make your system unbootable so its best to stay away from them, registrybooster is from uniblue and the jury is out on them, I would not have any programs from them or any reg cleaners on any of my systems
I deleted the file and could not find any evidence that it was installed. No entries in the Control-Panel/add-remove-programs. I found no directories in the c:/programs/ directory that seemed to be related to this program. Please let me know if I need to take any additional action.