I have been trying to solve this problem after installing windows 10 (after uninstalling spybot) it keeps coming back. says it has to uninstall the old version to install the windows 10 version. And If I let it, it still wont uninstall. Finally after searching the registry I found the folder.

Reg entry: HCU\software\Windows\currentversin\run\ (This was not showing up in the startup tab in task manager!

key: SpybotPostWindows10UpgradeReInstall
Value: "C:\Program Files\Common Files\AV\Spybot - Search and Destroy\Test.exe"

test.exe
Upgrade.exe
upgrade.log
Userdata.cab

and the log file says:
2016-04-25 15:17:34.321 Log opened. (Time zone: UTC-04:00)
2016-04-25 15:17:34.321 Setup version: Inno Setup version 5.5.5 (u)
2016-04-25 15:17:34.321 Original Setup EXE: C:\Program Files\Common Files\AV\Spybot - Search and Destroy\Upgrade.exe
2016-04-25 15:17:34.321 Setup command line: /SL5="#################,C:\Program Files\Common Files\AV\Spybot - Search and Destroy\Upgrade.exe" /LOG="C:\Program Files\Common Files\AV\Spybot - Search and Destroy\Upgrade.log"
2016-04-25 15:17:34.321 Windows version: 6.3.9600 (NT platform: Yes)
2016-04-25 15:17:34.321 64-bit Windows: Yes
2016-04-25 15:17:34.321 Processor architecture: x64
2016-04-25 15:17:34.321 User privileges: Administrative
2016-04-25 15:17:34.321 64-bit install mode: Yes
2016-04-25 15:17:34.446 Created temporary directory: C:\Users\#####\AppData\Local\Temp\is-A5UNK.tmp
2016-04-25 15:17:34.618 Extracting temporary file: C:\Users\#####\AppData\Local\Temp\is-A5UNK.tmp\SDCreateWin10UpgradeUserDataLib.dll
2016-04-25 15:17:34.878 Extracting temporary file: C:\Users\#####\AppData\Local\Temp\is-A5UNK.tmp\isxdl.dll
2016-04-25 15:17:38.255 Message box (Yes/No):
Setup is not complete. If you exit now, the program will not be installed.

You may run Setup again at another time to complete the installation.

Exit Setup?
2016-04-25 15:17:42.462 User chose Yes.
2016-04-25 15:17:42.462 Deinitializing Setup.
2016-04-25 15:17:42.572 Log closed.


So I think this is pretty much what was doing it... and I could not stop it from running on boot and aggravating my girlfriend to no end.