FYI, I got the below working on my Windows 10 Home Edition 64 Bit Version 2004 HP PC using the following files from Spybot Tech Support: spybotsd-2.8.68.0 & SpybotLPTests.v2:

Windows Fixes and Spybot Fixes to have both Spybot S&D and Windows Defender Operational

After installing spybotsd-2.8.68.0 & SpybotLPTests.v2 in that sequential order:

Launch the Registry Editor in the Tools tab in the System Configuration app in the Windows Administrative Tools folder in the Start Menu.

In the Registry Editor, start from the top of the file structure at Computer to find "SDWSCService" and modify its LaunchProtected value to zero (0).

Close the Registry Editor.

Close the System Configuration app.

Restart Windows.

Open the Spybot S&D Start Center app.

Right click on the Settings icon and click “Run as Administrator”.

In the System Services tab in Settings Stop the Security Service Center.

Click Apply in Settings.

In the System Services tab in Settings Uninstall the Security Service Center.

Click Apply in Settings.

Click OK in Settings.

Close the Spybot S&D Start Center app.

Restart Windows.

Ensure that the Windows Defender is fully active in the Windows Security Service Center, Spybot S&D is no longer in the Windows Security Service Center and Spybot S&D is fully active in its System Tray icon.

The above without installing SpybotLPTests.v2 would have to be done after the installation of each subsequent release/version of Spybot S&D starting with the next release/version of Spybot S&D after Spybot S&D 2.8.68.0.

Use the above at your own risk as I assume no responsiblity for the above.