While browsing in edge, I received a Ransom FBI ad and I powered off computer.
After Reboot, edge did not work.
Reboot again and I received a Quarantine Request and I said yes.
After that edge and outlook would fail w/o error message.
Ran as admin and I would get message:
"Windows can not access the specified device, path, or file. You may not have the appropriate permissions to access the the item"

I receive this message for outlook also which was open at the time.

Word or excel does not work either