No way to reproduce this, at least not that I am aware of, so it is posted only to report that it happened:

Installed v. 1.5.1.14, went into Immunization, where I was told that it likely would not work unless I logged on as Administrator.

Given that I am the administrator, I was quite puzzled by that message, and by noticing that Firefox and Mozilla were not showing on the Immunization screen.

Tried to get into the help file to see if anything there would assist, but the help files did not work.

Restarted Spybot, and Immunization included Firefox and Mozilla, and worked correctly.When it was done, I tried Help, which also worked.

So, all I can do is report a possible start-up problem; if no one else encounters this, then it must have just been a "This happened, sorry" event.