I've been using Spybot for quite a long time, but I've never run into this little oddity before...
I'm running Windows 7 32-bit
Whenever I go to open the setting, Spybot persistently pops up a window saying "no cd in drive" - if I put any cd in the drive, it shuts up and lets me do what I want, no problem.
I'm not trying to run it off a cd, it's installed on my system and (otherwise) works just fine.
Thoughts?