You do need to close Firefox, because Immunization is trying to alter a file currently in use (hostperm.1 or cookperm.txt in versions older than 3, permissions.sqlite afterward).
You do need to close Firefox, because Immunization is trying to alter a file currently in use (hostperm.1 or cookperm.txt in versions older than 3, permissions.sqlite afterward).
On SpyBot Search & Destroy startup, it warns the user if a browser is open. It makes the assumption that the user will heed the warning and close all the browsers.
If Firefox is still in the Task Manager, then it really didn't close. Sometimes, an extension can cause this, especially those added by AVG or Norton.
For the past few updates, there have been no new immunizations included, so immunize has no work to do. That is likely what you are seeing. I always make sure that Firefox closes completely (never had the problem with it staying in the Task Manager), and I always close all browsers.