When using advanced mode, some items listed in system startup are highlighted in yellow.
This is from the help file:
This tool lists all programs that are started at Windows startup. If those items are in the database coming with Spybot-S&D, it will display some more information about them. It also allows you to disable (and enable) items, as well as delete them, change them or insert new items.
The entries will be displayed in different colours:
Green: legitimate program
Yellow: unknown, unneeded or unambiguous program (e.g. malware programs might use the same file name as legitimate programs)
Red: malicious program
On Windows 9x and ME, the user has full access to this list. On Windows NT/2000/XP, the list will display the global and the current user entries. For some functions like seeing all entries or even changing some, the user may need admin or power user rights.
New feature since version 1.3: entries that have changed since the last snapshot (the first snapshot is created when you started Spybot-S&D for the first time, later on you can create snapshots by right-clicking the list and selecting the corresponding menu item) are displayed in bold letters. This allows you to see changes to the list at once.