In other words, Spybot scans the portion of the drive(s) required automatically.
There is a special scan for Spyware installers (files not installed yet) that can be limited to specific directories (actually it should be limited) which can be located on either internal or external drives. To activate this feature go into Spybot > Mode > Advanced mode > Settings > Directories and add directories. There is more on what this feature scans for here:
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