Denied Access

[bignoob]

seems like spybot is being denied access when it scans, i get a list stuf like this :
Error during check!: Dummy [1 - $649C5A6E] (Cannot open file "C:\WINDOWS\System32\drivers\etc\hosts". Access is denied) (Status)


anyone can help this noob to fix this crap? pls

[Zenobia]

Is access to the hosts file the only thing denied?
Do you have any programs installed that might "lock" the hosts file?
Anything like Spysweeper?
Or Zone Alarm or Stopzilla?