Immunize Global (Hosts)

Immunize Global (Hosts)
I have a new HP computer with Windows 10
Spybot 2.4 + av is installed.
Immunization does not complete on Global (Hosts) C:\Windows\System32\drivers\etc
There are 0 protected and 15,494 unprotected. I did run as administrator more than once.
All updates are complete and a scan was run.
How do I complete immunization?
Thanks
Frank C

Hi,
I read that firewalls could interfere with immunize. I have Webroot so I tried with the firewall off, it didn't help. Windows Defender is not in use.
I still have 15494 unprotected. The HOSTS file has no entries. I also checked permissions on HOSTS, System, Administrator and my user id, all have full control. I ran Immunize as administrator
How can I get Immunize working?
Thanks
Frank C