I know this thread is old but I wanted to say thanks for the tip. After unticking the check mark next to "Scan programs before they start" I stopped encountering the error "Runtime error 217 at 500E8338".
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Really appreciate you confirming this as a possible solution. Win10, DevPreview edition. Same "Runtime error 217 at 500E8338" error started when I upgraded SpyBot. Just tested this solution. I'll return to the thread and check with support if it doesn't solve it for me also.
Bummer that feature causes run time error.