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http://a4nic8er.com/images/SSandD/SSD-immincomp100804.jpg
Possibly related: The time taken to load and unload registry hives appears to be increasing when opening and closing SS&D as the number of...

It's a 64-bit problem.

Spybot will only immunize when run as administrator, so yes.

Thanks, tried that. Did not fix. The problem is not that Spybot fails to immunize IE completeley but that, since the "base trojan...

8910 items unprotected.
2709 in Internet Explorer (64 bit) \SOFTWARE (Domains).
6204 in Internet Explorer (64 bit) \SOFTWARE (Secure Domains)

8349 items unprotected.
2192 in Internet Explorer (64 bit) \SOFTWARE (Domains).
6157 in Internet Explorer (64 bit) \SOFTWARE (Secure Domains).

7377 now

1301 Unprotected in Internet Explorer (64 bit) \SOFTWARE (Domains).
6076 Unprotected in Internet Explorer (64 bit) \SOFTWARE (Secure Domains).

Oh wait, a patch is available.

Make...

Sorry for the delay, had pretty much given up on getting a response to this problem.

Tried your suggested solution, but that only clears the 32 bit IE Immunization data.
So I deleted the...

I now have 3465 immunization failures in IE (64 bit) \SOFTWARE (Secure Domains).

2337 now

2277 now

New update, same old crap.

Chased the failed immunizations around the various sections for a while until I stumbled accross a method for quickly geting them all into IE (64 bit) \SOFTWARE (Secure...

Latest update: No better, worse if anything.

2193 Immunization failures, spread all over.

http://a4nic8er.com/images/SSandD/SSD-immincom7C.PNG

Took 10 -15 minutes of rebooting into safe...

Ok. Tried that, several times. Appeared to work until reboot into normal mode but I suspect it was just moving the unprotected items around again. Upon normal restart and Immunization check, I end up...

Yes. I did that and quite a few other things. My actions and the interesting results from them can be easily followed by reading page one of this thread.

*edit* There's even a couple of...

No such issues with XP Pro 32 bit or Windows 7 RC 64 bit on same machine, only XP Pro 64 bit.

http://a4nic8er.com/images/SSandD/SSD-immincom4E-W7.png

Updated SS&D (yes both updates - screenshot taken midway through update).

http://a4nic8er.com/images/SSandD/SSD-immincom4A_upd.PNG

Immunized, 1869 items failed (up from 1737, an increase of 132...

@ Hoffmaister: are you running XP Pro 64 bit?

Here's what I have done to try and trace the cause of this problem...

Isolated from internet.
Restored to image from 30 November 2009...

OK, tried that. Unfortunately all it did was change the sections where the 969 non-immunized items are. See attachment and compare it to the one in my previous post.

Sorry, I can't.

I could try rolling back to a drive image recorded before this issue arose and then apply the Windows Updates one-at-a-time, recording another image after each update then...

Now at 969 items failing to immunize after latest Windows Update x64 IE8 security patch followed by Spybot S&D update. No such issues with XP Pro 32 bit.

Same problem here, been wrestling with it for weeks. I have NONE of the software listed in the "usual reasons" sticky thread.

Windows XP Pro x64
IE8
Avast Home
SpywareBlaster
Spybot S&D

I...