Update:
I uninstalled System Mechanic, as it seems to interfere with Kaspersky anti-virus update (Kaspersky is always asking me to reboot the computer). With SM removed, Kaspersky works fine and so does Spybot. I'm fully immunized and (touch wood) it seems to stay that way. I'll report back...
Have you tried doing a Recovery restore point prior to Spybot install? If that doesn't work, wipe your drive and reinstall Windows 10. It's faster doing that than waiting for a response.
I also have the same problem that Dude_Virus and agresywny reported...both Telemetry Hosts (under protection tab) and Telemetry Hosts - extensive list (under optional tab) do not keep the protection after you hit the "immunize" and "block" function respectively. I'm currently running Windows...
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