I run Spybot (with Teatimer), Webroot SpySweeper, Spyware Guard, Spyware Blaster, Trend Micro Anti-Spyware, Pest Patrol, V-Com System Suite,
( The preceding run in the system 24/7) along with daily checks via Arovax,, Crap Cleaner, Super Cleaner, Cleanup!, CWS Shredder, Rootkit Revealer...