I use Safernetworking 1 to download my Spybot updates.
In Seamonkey my download directory is C:\Utilities. In IE, which I don't use much, I browse to C:\Utilities or desktop.
IE is set to delete Temporary Internet Files upon closing and I delete the cache pretty frequently in Seamonkey (which is set to 25MB).
It seems Spybot scans the bookmarks from both browsers many times. It used to just scan each one once.
Sincerely, Libra