During the IMMUNIZE function of Spybot, a registry entry is added:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Internet Explorer\ActiveX Compatibility\{00000000-0000-0000-0000-000000000000} (DWORD binary: 400 ; hex: 1024)

Can you shed some light on the logic behind this setting? How is setting this registry setting protecting my machine from Spyware, and what risks specifically are mitigated with this setting?

We've found this setting to be incompatable with several Office 2007 proggies, and Microsoft recommends removing this key that was added by Spybot S&D. I need some info so we can make a decision. Thanks in advance!