What to do with this IE alert?

[GeminiAlpha]

Sometimes I get this alert:

Microsoft.Windows.Security.InternetExplorer: Instellingen (Registerwijziging., nothing done)
HKEY_USERS\S-1-5-21-1547161642-1757981266-725345543-1003\Software\Microsoft\Internet Explorer\Main\FeatureControl\FEATURE_LOCALMACHINE_LOCKDOWN\iexplore.exe!=W=1

What to do and what does it mean?

Tnx for help.
Rudolf.

[Yodama]

hello,

This item has been flagged because your IE settings have been changed to not restrict websites on your computer.

If you did not change this setting yourself to locally test websites you should have Spybot S&D fix this so that malware does not exploit this.

[GeminiAlpha]

Hi, I did not change this setting, so I will order Spybot S&D to 'repair' this.
Thanks for a very quick answer!
Rudolf.