katie_fleming:

I'm sorry but I did not see anything in the startup list that would cause the opening of the folder when you reboot.

The only thing that I can suggest is that you uninstall Spybot according to the instructions in How to uninstall?. After you have uninstalled, please make sure that you download and run this very small fix to ensure that the registry entries for Spybot have been deleted. Then reinstall using the spybotsd160.exe installation program that can be downloaded from Mirror selection - The home of Spybot-S&D!.