SpybotSD.exe - No disk

[ghwmd1]

New errror window indicating '...there is no disk in the drive. Please insert a disk into drive E...' when I try to scan. Running XP, SP3, fully up to date no other infections or malware present

Uninstalled and then reinstalled spybot, same error message

[spybotsandra]

Hello,

At first please make sure that you are running the latest version of Spybot - Search & Destroy including the latest updates.

To see which version number and/or updates of Spybot - Search & Destroy you are using please run Spybot-S&D and choose "Help" --> "About" in the menu bar.
There you can see which version you have and which updates are installed.
It should be version 1.6 and the updates from the 2008/11/26.

If this does not help this is a known problem which can occur in Windows.
The problem is usually cause by having Drive C assigned to a device with removable media. If you have that situation then either put media in Drive C or reassign the device to another letter.

There are instructions for reassigning the device to another letter here:
There Is No Disk in the Drive

Best regards
Sandra
Team Spybot