SpybotSD.exe - No disk

New errror window indicating '...there is no disk in the drive. Please insert a disk into drive E...' when I try to scan. Running XP, SP3, fully up to date no other infections or malware present

Uninstalled and then reinstalled spybot, same error message

Hello,

At first please make sure that you are running the latest version of Spybot - Search & Destroy including the latest updates.

To see which version number and/or updates of Spybot - Search & Destroy you are using please run Spybot-S&D and choose "Help" --> "About" in the menu bar.
There you can see which version you have and which updates are installed.
It should be version 1.6 and the updates from the 2008/11/26.

If this does not help this is a known problem which can occur in Windows.
The problem is usually cause by having Drive C assigned to a device with removable media. If you have that situation then either put media in Drive C or reassign the device to another letter.

There are instructions for reassigning the device to another letter here:
There Is No Disk in the Drive

Best regards
Sandra
Team Spybot