Have SS&D installed and have not had any problems using it (apart from some immunisation issues). Also have Spyware Doctor and following a scan, it picked up a Spyware.Possible_Website_Hijack detection within the Hosts file which it was unable to remove (, w*w.spywareinfo.com and spywareinfo.com). Contacted the Spyware Doctor help desk and this is their reply:

About Spyware.Possible_Website_Hijack detection, we have received an update from our Research Center about the issue.

The Spyware.possible_website_hijack detections you are experiencing is caused by Spybot.
Spybot appears to be detecting spywareinfo.com as malicious therefore it is utilizing the host file to prevent access to this site, however on Spyware Doctor's side this site contains no malicious entries therefore it is removing host file entries that are trying block access to legitimate sites, in this case spywareinfo.com.

I wonder if anyone else has had similar potential conflict issues and whether this is something I should be concerned about.