besafe: Since Spybot S&D works exactly as md usa spybot fan explained, my guess would be that Hosts Secure is causing the problem. I can change the Read-Only status of Hosts using either Windows Explorer Properties or Spybot S&D and see the other change, though I must refresh the Spybot Tweaks page to see the change since this isn't dynamically updated.
Here's something from the Hosts Secure Web Page that mentions how it also locks Hosts while the program is running, something Spybot S&D doesn't do.
If, as md usa spybot fan mentioned, you have another program that monitors the hosts file I'd be looking there for the conflict.Thursday, November 24, 2005 @ 4.18AM
Sorry about the lack of updates recently, school just started and I'm really busy. School's in 4 hours time and I've been up all night. Alright, enough whining. New version!
Changed the way the HOSTS file is locked. Instead of setting it to just read-only (which malicious software can easily un-set), it now locks the HOSTS file as long as the program (HOSTS Secure) is running.
Bitman