A week ago I deleted SpyBot completely. I re-installed it a few days ago and accepted all the updates. I'm also getting the Runtime Error 216 like others are getting.
I wish I had time to monkey around with all the suggested fixes, but I don't. I DID have time to run my Panda Rootkit Finder with a reboot, but it found nothing (A different rootkit finder was suggested in a previous posting). I could not get SpyBot "Tools>Bug Report" to send my bug report as suggested by Buster (below). The mail settings tripped me up (Thunderbird). I copied and pasted the "system generated report" into a standard e-mail along with the Configuration.ini file attached. Hope that is sufficient.
David