Dang......
couple of things to try
Unplug the computer from the power supply for a few minutes, plug stuff back in and reboot.?
Try a different USB port?
What does it do when you try to boot into safe mode?
try clearing the CMOS by turning off and unplugging your computer fully, opening up the computer and remove a battery, then place the battery back in carefully.
Reboot the computer and see if anything has been fixed?