I asked, in a ticket, about Spybot defeating or locking out Windows Defender. The reply was a quite understandable: "MS won't allow WD to run with any other AV program running." Got that. But...

Malwarebytes has a procedure that puts MBAM under WD's radar, and the two very much coexist. As soon as I added Spybot to the mix... WD said no way. So... what the heck did MBAM do that Spybot can't or hasn't done?

Quote Originally Posted by MBAM Support
[/...]Please do the following to reinstall Malwarebytes in a proper way:

Make sure, that your Antivirus software (Norton, Avast, Kaspersky… ect.) is switched off or uninstalled during the whole process!

If you can run Malwarebytes 3.0 make sure, that the Selfe-Protection module is disabled. Settings —> Protection —> scroll down to “Enable self-protection…”, slide the switch to “Off”.

If you can not run Malwarebytes 3.0, continue this workaround.

1. Uninstall Version 3.0 from the Windows control panel —> uninstall programs
2. Run our clean uninstaller tool mbam_clean.exe, you can download from this link below:

https://downloads.malwarebytes.com/file/mb_clean

3. Restart your computer and download the newest version from here:

https://downloads.malwarebytes.com/file/mb3/

Proceed with the installation after uninstalling the previous version.

Note: If you get an error message about a file, which can not be replaced, click on “IGNORE”.

Restart your machine and test whether the issues persist.[/...]
Let the fun begin...