For the last several months, I have noticed that whenever I run the Immunization Application, I get the exact same results:
(1) It always says "You haven't used Immunization in more then ten days. We recommend to check the current state". It says this regardless of when I last ran the application.
(2) The Immunization check finishes, and tells me "All 221934 entries are immunized". The immunization never reports a problem, and the entry count is always the same.

The program is running with administrator privileges. The 'details' page shows everything is protected (no unprocessed and no unprotected). The 'Testing Immunization' progress bar moves along nicely, going through the various lines of the 'details' page.

If I have a browser open when I start the immunization, I DO get an extra status message about needing to close the browser for immunization to be successful.

I am running Spybot+AV Home Edition, Version 2.6.46.0