SpyBot is still causing tons of Vista problems. The installer does not properly add it to the Security Control Panel. Immunization causes an edit to the HOSTS file, which is not recommended in Vista because the HOSTS file is used for more than just web browsing. SpyBot attempts to write protect all files in the System32 folder which is a big no-no since Vista can then not properly open it's own Control Panel, use 3D-Flip, and shuts down Software Licensing Service.
Disappointing for what was once a pretty faithful program.