At least this was the problem for me. There are browsers open in task manager in the background. If the browser processes are ended, the program responded immediately. If the browsers were open in the background, "fix selected" would take 10 minutes to work and the program showed "not responding" in the meantime. You can fix this by going to advanced settings in Chrome and turning off the option to run chrome in the background under the System option. In Internet Explorer go to Advanced settings and uncheck the option to "Enable third party extensions". I'm not sure what other effect turning these off will have, but Spybot should work properly again.