Immunization is creating those registry keys to protect you from those domains. Actually Spybot creates many registry keys, not just for those two sites when it immunizes. As I recall, the reason those registry keys are made is to place the sites into security zones:
https://www.yourdictionary.com/security-zones
Spybot would be placing them into the restricted security zone for your protection. As long as Spybot is placing them into the proper security zone, these registry keys are not dangerous.
adwcleaner might consider these registry keys dangerous because it may be a false positive. There's an article that explains roughly what a false positive is here, near the top of the article:
https://www.howtogeek.com/180162/how...alse-positive/
I don't know my way around their forum, but you might be able to find a place to report a false positive somewhere here:
https://forums.malwarebytes.com/foru...es-adwcleaner/