Please have a look at the "Directories" in the "Settings" when you run Spybot - Search & Destroy in "Advanced Mode". There you can add additional harddisks or folders.
You can also use the command line parameter allhives.
/allhives
Scans all windows installations on your system, even inactive ones.
Example: "C:\Program Files\Spybot - Search & Destroy\SpybotSD.exe" /allhives http://www.safer-networking.org/en/faq/30.html
Also to mention the File Scanner - you can scan every single file with it.
(SDFiles.exe in the program folder if you did not select it during installation to appear in Explorers context menu).
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