To the best of my knowledge the communication is http via Port 80.
Firewalls:
In most firewalls you have to authorize SpybotSD.exe to access the internet.
If you are sitting behind a proxy server:
Go into Spybot > Mode > Advanced mode > Settings > Settings. About 2/3 of the way down the option tree there is a category "Web update". Check the last item in the list "Use proxy to connect to update server". A pop-up will come up were you can enter the information required.
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