Which version of Spybot do you run?
Which browser do you have installed?
Which windows version do you have?
Are you logged in as admin?
Do you run any other security software that might block the immunization?
Please try the following:
1. Start your PC in safe mode.
2. Launch Spybot.
3. Unselect all the options in the immunization tab except the ones which are not immunized.
4. Undo Immunization.
5. Redo Immunization.
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