Just installed Spybot Search and Destroy on top of
Comodo FireWall Pro (firewall)
DriveSentry (file and registry protector)
VirusScan Enterprise (av)
and
System Safety Monitor (HIPS)
AdMuncher (ad/banner killer for IE/Opera/FF)
No problems so far.
They all seem to work in harmony with each other.
Comodo FireWall Pro (firewall)
DriveSentry (file and registry protector)
VirusScan Enterprise (av)
and
System Safety Monitor (HIPS)
AdMuncher (ad/banner killer for IE/Opera/FF)
No problems so far.

They all seem to work in harmony with each other.