Spybot & Trend Micro
I currently use Trend Micro Internet Security 2006 and use Spybot 1.4 (previously used 1.3 also)(also prior versions of Trend Micro) together with the Tea Timer ON with no problems. The real time scan isn't always looking for the same things. Trend Micro prior version didn't look for spyware. Spybot has been doing it longer and I think is better at catching spyware, although I highly recommend Trend for viruses! I also use Trend's office products (Office Scan, Scan Mail) on Windows Server 2003 and on Windows 98 & ME machines as well as XP Pro. All run with Spybot Tea Timer and resident IE. Wouldn't dream of running them any other way these days!