I rarely reboot my laptop... though I did it twice ater installing some updates & software recently and it was then I noticed the Telemetry Hosts (extensive list) in anti-beacon not holding.
I've now just rebooted twice again and it is now staying blocked!... so dunno what's going on there... user error probably, or maybe some soft on my machine that's resetting it... i'll keep an eye on it, though I'm sure it's all good now.
It's set & forget mostly I think, but just check periodically for updates in the about box.
Cheers.