I've had a problem with the Symantec AntiVirus Corporate that we use at work where AntiSpyware and AntiVirus would detect the same malware and both try to quarantine them (or temporarily lock file access to it) at the same time so neither one could delete the threat. I just can't remember whether that AntiSpyware was Microsoft's Defender or Spybot S&D. But in disgust I uninstalled AntiSpyware and haven't gone back until recently I decided to give Spybot S&D another shot... again until I read this article and realise some things will never change...