What Operating System are you using? What Internet Borwser are you using (IE, FF, Opera)? Clarify your problem and elaborate.
Do you have TeaTimer or SDHelper (Spybot-SD's blocker for bad downloads") active? Have you tried clearing your cache, temp. files, and cookies in your browser? Find it under TOOLS and "INTERNET OPTIONS".
Have you cleaned your "browser tracks"? Also, do you have the latest version of Spybot-SD (1.5.2.20)? Perhaps a dated version may be conflicting.
If Spybot-SD 1.5.2.20 works fine then its good. But you can change settings in Spybot-SD in Advanced Mode. But I would strongly NOT recommend it if you are unfamiliar with ADVANCED MODE.