I download the beta updates on a regular basis and have never really had a problem doing that.
I do however take a precaution when running the ßDetection rules (Beta.sbi file) because of a higher likelihood of false positives in newly written rules. I run a Spyware scan without the ßDetection rules then run another scan with just the ßDetection rules. That way my results are separated so that I can tell if a detection was caused by the ßDetection rules.
I described this technique in Post #13 and Post #16 of the following thread:
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