I used Spybot to remove an infection with Virtumonde a couple months ago. At some point during the virus removal process, I must have blocked a process or change and now I cannot make changes to my IE settings.

I can access Internet Options, make any changes I want and save, but it will not retain the settings. I can change my homepage with no problem, it will save that, but nothing I configure on the advanced tab. I have unchecked every possible setting I can find for IE in Spybot but can't figure it out. Can anyone tell me how to get control of IE back? The pop-ups are driving me nuts.