It depends on the software.
There is a lot of monitoring software out there and we have quite a lot in our detections. If it is not found in a scan we should be able to see it in a bug report.
But another thing is that this pc that you are talking about needs to be licensed in it's use of Spybot. Spybot Search and Destroy is only free for the private use.
The license agreement is available here.
To use Spybot in a corporate environment you need to purchase a license.
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