It was designed from the beginning to run wherever you want Even from bootable CDs (where you don't even have write acces) through a PE disk... so: just try it, you don't even need to install it there, it should be sufficient to copy the program folder of any installation onto the stick
At the moment, we have to check if the creator haven't change anything security related so that we can allow it.
Apart from that, Spybot-S&D can be easily used with an USB stick, even if the solution is not perfect. Just install it on the PC and then copy the installation folder on the USB stick.
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